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Table 2 Prognostic factors for overall survival and recurrence-free survival by the univariate Cox proportional hazards regression model

From: NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner

Variables Overall survival Recurrence-free survival
HR 95% CI P HR 95% CI P
Age 0.998 0.979–1.018 0.872 0.998 0.984–1.013 0.807
Gender (F/M) 0.922 0.481–1.769 0.807 0.920 0.574–1.475 0.729
HBsAg 1.581 0.908–2.753 0.105 1.394 0.798–2.437 0.243
AFP (≥400/< 400) 1.335 0.943–1.891 0.104 1.799 1.252–2.586 0.001
Ascites (+/−) 1.057 0.451–1.986 0.884 1.693 1.025–2.797 0.040
Tumor size (> 5/≤5) 1.755 1.246–2.530 0.002 1.440 0.998–2.077 0.051
Multiple tumors 1.754 1.161–2.652 0.008 1.734 1.114–2.698 0.015
Differentiation (Poor/Well-Moderate) 1.188 0.842–1.678 0.327 1.081 0.751–1.560 0.671
TNM stage (III/I-II) 1.325 0.902–1.946 0.151 1.456 0.973–2.177 0.067
Macrovascular invasion 3.039 1.408–6.556 0.005 2.739 1.268–5.915 0.010
Microvascular invasion 2.621 1.846–3.721 0.001 2.337 1.621–3.369 0.001
Cirrhosis 1.191 0.832–1.707 0.339 1.174 0.803–1.715 0.407
NCSTN (high/low) 1.721 1.203–2.460 0.003 1.566 1.080–2.272 0.017
  1. TNM Tumor-node-metastasis, HR Hazard ratio, CI Confidence interval, F Female, M Male