Fig. 2From: Hypoxia, metabolism, and the circadian clock: new links to overcome radiation resistance in high-grade gliomasHigh-grade gliomas (HGGs) have multiple characteristics that contribute to their aggressive behavior. Increased levels of HIF, glycolysis and radioresistance are common. Circadian dysregulation has also been identified as a recent characteristic contributing to growth, stemness and metabolic changes observed in HGGsBack to article page