Fig. 1

FTL is overexpressed and associates with prognosis in high grade glioma (HGG). a FTL mRNA expression in low grade glioma (LGG) and HGG in TCGA and CGGA datasets; b FTL mRNA expression in patients with wildtype and mutant IDH1/2 in TCGA and CGGA datasets;c Representative images of IHC staining of FTL in glioma tissues, GBM, glioblastoma;d Chi-square test was used for comparison between groups; e Western blot was performed to compared FTL expression in LGG and GBM, LGG, n = 14;GBM, n = 14,GAPDH used as loading control; f The images represented as the mean ± SD of three independent experiments.g Kaplan-Meier survival analysis for FTL expression in all glioma patients in TCGA and also analysis the prognostic role of FTL in HGG and LGG (h and i). The median value of FTL levels was set as the cut-off level. HR, hazard ration; CI, confidence interval. ***, P < 0.001, as compared to control