Table 3 Role of HDACis in Cancer
From: The application of histone deacetylases inhibitors in glioblastoma
pathway | genes/signalings | tumours affected | representative drug |
|---|---|---|---|
apoptosis | TNBC and pancreatic cancer | SAHA, NaB , VPA and TSA | |
proapoptotic proteins of Bcl-2 family, such as Bim, Bmf, Bax, Bak and Bik ↑ antiapoptotic proteins of Bcl-2 family, such as Bcl-2, Bcl-XL, Bcl-w and Mcl-1 ↓ [93] | melanoma | SBHA | |
Mesothelioma and leukemia | LBH589 and LAQ824 | ||
TBP2 ↑-Trx ↓-ASK1 signaling ↑ [100] | prostate cancer | SAHA | |
ROS ↑ [101] | CLL | MS-275 | |
TRAIL-DR5 ↑ FASL-FAS (Apo-1 or CD95) ↑ | leukaemia, breast cancer | VPA, SAHA and TSA | |
human RAD23 homolog B (HR23B) ↑ [104] | U2OS cells | SAHA | |
breast cancer | TSA and LAQ824 | ||
cell death | NF-κβ ↑ [107] AKT-mTOR signaling ↓ [94] | Prostate Cancer glioblastoma | SAHA SAHA |
cell arrest | CML-BC cells, colon cancer and bladder carcinoma | LAQ824, SAHA and Butyrate | |
p27 ↑ [111] | leukemia and breast cancer | SAHA and TSA | |
GADD45 α and GADD45 β ↑ [112] | colon carcinoma | TSA and Butyrate | |
TGF-βRII ↑ - c-MYC ↓ [113] | Ewing's sarcoma (EWS) and neuroblastoma | MS-275 | |
angiogenesis | HIF-1a ↓ [114] VEGF ↓ [115] | Lewis lung carcinoma HepG2 cell | FK228 TSA |
DNA repair | Ku86 ↓ Ku70 ↓ [116] | melanoma cells | sodium butyrate (NaB) |
RAD51 ↓ BRCA1&2 ↓ [117] | human squamous carcinoma cells (SQ-20B) | TSA | |
immunity | MHC class I genes ↑ tumor antigens ↑ PD-1 ligands ↑ [118] | melanoma | LBH589, MS-275 and MGCD0103 |
Treg cells ↓ [119] | renal and prostate cancer | entinostat |