From: The application of histone deacetylases inhibitors in glioblastoma
alterations | affected part | agents |
---|---|---|
p21Waf1/Cip1, p27↑ | cell cycle arrest | SAHA [151], I-BET151 [164], TSA [165], NaB [166], PB [167], FK228 [168], DATS [169], PXD-101 [170], NBM-HD-3 [171], Scriptaid [172], MS-275 [173] |
DR5, TNFα, p53, Bad, Bax, Bim, chop, Puma, m-calpian↑ | proapoptotic genes | SAHA [151], TSA [166], NaB [166], VPA [174], FK228 [152], DATS [169], PXD-101 [170], DWP0016 [175] |
vasculogenic mimicry, VEGF, EGFR↓ | angiogenesis | SAHA , MS-275, MC1568, TSA [176], NaB [177], DATS [169], LBH589 [178] |
Bcl2, Bcl-XL↓ | antiapoptotic genes | |
EZH2, MMP-2↓ | invasion | |
p-PTEN/p-AKT, pFAK/p-STAT3↓ | pathways | |
CDK2, CDK4, CDK6, cyclins D1, cyclins D2↓ | progrowth genes | |
caspase 8, caspase 9, caspase 3 | apoptotic cascade activation | |
HOTAIR↓ | tumor promoting lncRNA | I-BET151 [183] |
Ras, c-myc↓ | oncogenes | |
CD133, Bmi1↓ | GSCs markers | SAHA [182] |