Fig. 5

MAPK4 knockout affects the sensitivity of cervical cancer cells to PARP1 inhibitors. a Relative cell viability of SiHa or caSki MAPK4 WT cells and MAPK4 KO cells after treatment with different concentrations of olaparib or veliparib, as determined by CCK-8. IC50 was calculated using the sigmoidal dose-response function of GraphPad Prism. b Relative cell viability of SiHa MAPK4 WT cells, MAPK4 KO cells, MAPK4 KO with MAPK4 over-expression cells (MAPK4 KO + MAPK4 cells) and MAPK4 KO with CA-AKT over-expression cells (MAPK4 KO + CA-AKT cells), as determined by CCK-8. IC50 was calculated using the sigmoidal dose-response function of GraphPad Prism. Data are expressed as the mean ± SEM