Fig. 4
From: CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma
Enhanced cathepsin B promotes migration and collective invasion. a. Representative images of immunohistochemical staining of cathepsin B in paired tumor and paratumor tissues. Scale bar, 200 μm. b. Western blot analysis of cathepsin B in Huh-7 and HepG2 cells transfected with indicated constructs. c-d. Quantitative analysis of migration ability of Huh-7 (c) and HepG2 (d) cells transfected with indicated constructs or treated with CA074. *** p < 0.0001, one-way ANOVA. e. Representative images of HE staining of 3D cultures of Huh-7 and HepG2 cells transfected with indicated constructs or treated with CA074. Scale bar, 200 μm. Graph shows quantitative analysis of relative invasion distance. * p < 0.05, *** p < 0.0001, # p > 0.05, one-way ANOVA