Fig. 3

In vivo BLI and gross and microscopic examination of pancreas. Representative BLI at the end of the study period and total photon flux (p/s) induction from pancreas at 6, 11 and 22 weeks of age¹ (a), pancreas/body weight percent ratio (b), representative pancreas histology (c, original magnification: 100X, scale bar: 200 μm), and cumulative incidence of PaC (d) in control (Ctr), diabetic (Diab), and Diab treated with FL-926-16 (Diab+FL) KCM mice at the time of sacrifice. Statistical significance between groups for pancreas/body weight percent ratio (a) was calculated using one-way ANOVA followed by the Student-Newman-Keuls test for multiple comparisons. Each dot represents one case and bars represent mean ± SEM. Statistical significance for PaC incidence (b) was assessed using the Chi-squared test and Fisher’s exact test. **P < 0.01 vs Ctr; †P < 0.05 vs Diab. Is = islet, * = invasive PaC, arrows = PanINs. ¹Except for three Diab and one Diab + FL mice, which were killed 5 and 3 weeks, respectively, before the end of the study (see “Results” section for further details).