Fig. 7

Effect of diabetic serum on human PDA cell proliferation. Mia PaCa-2 cell proliferation after 48 h incubation with medium containing 10% of serum from healthy, non-diabetic (ND) subjects or diabetic patients before (Diab) and after AGE removal in the absence (Diab-AGEs) or presence (Diab-AGEs+FL) of FL-926-16 (20 mM), and relative representative bright-field images (original magnification: 100X, scale bar: 200 μm); n = 5 wells in duplicate per condition. Each dot represents one well and bars represent mean ± SEM. Post hoc multiple comparison: ***P < 0.001 vs ND; †††P < 0.001 vs Diab; ‡‡‡P < 0.001 vs Diab-AGEs