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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)

Fig. 1

a The “Cytokine-cytokine receptor interaction” signaling is a prominent transduction pathway associated with the expression of HIF-1α in TNBC patients. The top 250 genes correlated with HIF-1α in the TCGA dataset were clustered using the KEGG pathway enrichment analysis. The x-axis and the y-axis indicate respectively the −log10-adjusted p-value and the different KEGG pathways. The number of the genes represented in the identified pathways is plotted on the right of each bar. The genes belonging to the “Cytokine-cytokine receptor interaction” pathway (listed in the pink box) were ordered by their HIF-1α correlation coefficients (from high to low) (see Additional file 1). b GSEA confirms an enrichment of the genes belonging to the “Cytokine-cytokine receptor interaction” pathway in the TNBC patients with high HIF-1α levels, as indicated. The patients of the TCGA and METABRIC datasets were ranked in accordance with the differential HIF-1α expression levels. c GSEA reveals an enrichment of the “HIF-1 signaling” genes in the TNBC patients with high IL-1β expression. Patients of the TCGA and METABRIC datasets were ranked in accordance with the differential IL-1β expression levels. Enrichment scores (ES) and relative p-values are plotted

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