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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis

Fig. 6

The miR-216b/JMJD2C/HIF1α/HES1 signaling axis participates in cisplatin-induced apoptosis in vivo. a Representative images of transplanted tumors from nude mice. b The growth of OS xenograft tumor in nude mice was measured every 7 days. c Tumor weight in nude mice. d miR-216b expression was determined by RT-qPCR in tumor tissues of nude mice, relative to U6. e Representative Western blots of Ki67, Bcl-2, JMJD2C, HIF1α and HES1 proteins and their quantitation in tumor tissues, relative to β-actin. * p < 0.05 vs. mice treated with Lv-oe-NC; # p < 0.05 vs. mice treated with Lv-oe-NC + Cis; & p < 0.05 vs. mice treated with Lv-oe-miR-216b + Lv-oe-NC + Cis. Data are expressed as mean ± standard deviation. Data in panel (a) and (c-e) were compared using one-way ANOVA with Tukey’s test, while data in panel (b) were compared by repeated measures ANOVA with Bonferroni test. n = 10 for mice upon each treatment

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