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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET

Fig. 3

CREB5 regulates MET and binds directly to the MET promoter. a The MET promoter sequence was cloned into pGL3-Basic vector containing the luciferase reporter gene and then transfected into CRC cells with the indicated treatments. b Schematic diagram of the full and truncated MET promoter. c The full-length MET promoter or its truncations were cloned into pGL3-Basic vector containing the luciferase reporter gene and then transfected into HCT116 cells with CREB5 shRNA or empty vector. d ChIP analysis of CREB5 binding to the MET promoter in SW480 cells. ** p < 0.01

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