Fig. 7

SOCS1 is indispensable for oncogenic function of LINC00669 in NPC cells. a, MTT assay showing knockdown of SOCS1 partially rescued the time-dependent proliferation defect in the LINC00669-depleted NPC cells. NC, negative control; siLINC, siRNA-mediated silencing of LINC00669; siSOCS1, siRNA-mediated silencing of SOCS1. b, Transwell assay showing reverse of the impaired invasion by knockdown of SOCS1 in the LINC00669-depleted NPC cells. * p < 0.05, *** p < 0.001 versus NC group. c, Wound-healing assay showing restoration of the migrative defect by knockdown of SOCS1 in the LINC00669-depleted NPC cells. * p < 0.05, ** p < 0.01, *** p < 0.001 versus NC group. d, Representative flow cytometry plots showing knockdown of SOCS1 abolished the massive apoptosis in the LINC00669-depleted NPC cells. * p < 0.05, ** p < 0.01, *** p < 0.001 versus NC group