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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2

Fig. 6

FadA up-regulates E-cadherin/β-catenin activation and chk2 to induce DNA damage in CRC cells. a Tumor number, size, and load in APCMin/+ mice on 12th week after treatment with WT or FadA−/− Fusobacterium nucleatum. b Protein expression of FadA, E-cadherin/β-catenin, and chk2 in CRC tissue determined by Western blot analysis. c Protein expression of β-catenin in the nucleus. d Representative micrographs showing β-catenin (400 ×), chk2 protein (400×), and γH2AX (400 ×) immunohistochemistry in CRC tissues. Data are expressed as mean ± s.d. Data from two groups were compared using the unpaired t test

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