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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway

Fig. 1

The expression level of hsa_circ_0002577 in EC tissues and cell lines and its clinical significance. a The relative expression levels of circRNAs in EC and paired adjacent normal tissue samples (n = 3) were analyzed using qRT-PCR and the expression heat map was generated using program R. b The expression of hsa_circ_0002577 in EC vs. normal tissues (n = 84) and in patients with FIGO stage I/II vs. stage III/IV. c Schematic illustration of hsa_circ_0002577 formation via the circularization of a segment in WDR26 gene (Genome Informatics, https://genome.ucsc.edu). d The Kaplan-Meier survival analysis of EC patients with high (n = 42) and low (n = 42) expressions of low hsa_circ_0002577. e Representative images of FISH analysis of hsa_circ_0002577 in normal and EC tissues. f The relative expression of hsa_circ_0002577 in human endometrial endothelial cell (hEEC) and EC cell lines (HEC-1-B, AN3-CA, KLE, HEC1-A, and Ishikawa). g The circular RNAs in Ishikawa and HEC-1-B cells were enriched by RNase R treatment. The expressions of linear and circular RNAs in cells received RNase R or mock treatment were analyzed. h The relative expression of hsa_circ_0002577 in the nucleus and cytoplasm of EC cells were analyzed. GAPDH was used as cytoplasmic control and U6 was used as nuclear control

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