Fig. 4
From: Histone methyltransferase and drug resistance in cancers
Targeting HMTs reverses drug resistance. a, In cancer cells, HMT 1 up-regulation or HMT 2 down-regulation leads to drug resistance. b, Drug resistance caused by HMT 1 can be reversed by corresponding inhibitors. A double-target drug or HMT inhibitor combine with others (HDAC inhibitor, et al.) reverse resistance. Drug resistance caused by HMT 2 can be reversed by HDM inhibitors