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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma

Fig. 6

KIAA1522 signature correlates with TNF-NFκB-Cisplatin resistance in independent cohorts of adenocarcinomas. The KIAA1522 signature was generated by the collection of KIAA1522 down-stream genes and transformed to KIAA1522 signature score through GSVA algorithm. a Single-cell sequencing data from E-MTAB-6149 dataset was subjected to tSNE dimension reduction and clustering the NAPSA positive clusters were shown. b The KIAA1522 signature scores in KIAA1522 mRNA positive and negative adenocarcinoma single cells were compared, t-test, ****P < 0.0001. c 3D plot shows the distributions of KIAA1522 score levels according to TNFα signaling score, NFκB activity score and cisplatin resistance score. d Heatmap shows the scaled GSVA score of a collection of TNF-NFκB-Cisplatin resistance signatures in adenocarcinoma single-cells within E-MTAB-6149 dataset in parallel with KIAA1522 mRNA expression and KIAA1522 signature score. e In multi-central ADC samples, meta-analytical evaluation of the correlation between KIAA1522 signature score with TNF signaling, NFκB activity and cisplatin resistance signatures. Forest plots show the correlations together with the 95% confidence intervals, and the fixed-model estimated correlation in each geneset. f Systematical univariate cox analyses estimate the Hazard Ratio of KIAA1522 signature score in multiple datasets from TCGA or GEO databases. The meta-analysis was performed by fixed model to estimate the prognostic effect of KIAA1522 signature score. g-h In GSE14814 datasets, adenocarcinoma patients receiving platinum-based chemotherapy were grouped according to KIAA1522 signature score alone (g) or the combination of KIAA1522 signature score and NFκB activity score (h), then survival rates of each group were revealed by Kaplan–Meier survival analyses. i Alluvial diagram of KIAA1522 signature score, NFκB activity, combined KIAA1522_NFκB score and the survival outcome

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