From: The role of extracelluar matrix in osteosarcoma progression and metastasis
ECM protein | Expression in OS | Roles in OS | References | |
---|---|---|---|---|
Collagens | Collagen I | Increase | Invasion and metastasis | [26] |
Collagen III | Increase | Chemotherapy resistance | [27] | |
Collagen IV | Increase | Angiogenesis | [28] | |
Collagen V | Increase | Adhesion | [29] | |
Collagen XVIII | Decrease | Anti-angiogenesis | ||
Cell growth and Metastasis | [32] | |||
Fibronectin | Â | Increase | Adhesion | |
Chemotherapy resistance | [36] | |||
Metastasis | ||||
Invasion | [39] | |||
Laminins | Â | Increase | Adhesion | [40] |
Invasion | ||||
Proteoglycans | Biglycan | Increase | Cell growth | |
Decorin | Decrease | Migration | [45] | |
Cell growth | [46] | |||
Lumican | Increase | Cell growth | [47] | |
Adhesion | [48] | |||
Versican | Increase | Migration and invasion | [49] | |
HA | Increase | Proliferation and invasion | ||
Cell apoptosis | [53] | |||
Metastasis |