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Table 1 The ECM components involved in OS

From: The role of extracelluar matrix in osteosarcoma progression and metastasis

ECM protein

Expression in OS

Roles in OS

References

Collagens

Collagen I

Increase

Invasion and metastasis

[26]

Collagen III

Increase

Chemotherapy resistance

[27]

Collagen IV

Increase

Angiogenesis

[28]

Collagen V

Increase

Adhesion

[29]

Collagen XVIII

Decrease

Anti-angiogenesis

[30, 31]

Cell growth and Metastasis

[32]

Fibronectin

 

Increase

Adhesion

[33,34,35]

Chemotherapy resistance

[36]

Metastasis

[37, 38]

Invasion

[39]

Laminins

 

Increase

Adhesion

[40]

Invasion

[41, 42]

Proteoglycans

Biglycan

Increase

Cell growth

[43, 44]

Decorin

Decrease

Migration

[45]

Cell growth

[46]

Lumican

Increase

Cell growth

[47]

Adhesion

[48]

Versican

Increase

Migration and invasion

[49]

HA

Increase

Proliferation and invasion

[50,51,52]

Cell apoptosis

[53]

Metastasis

[54, 55]