Table 3 ECM as therapeutic targets in OS
From: The role of extracelluar matrix in osteosarcoma progression and metastasis
Therapeutic target | Functions | References | |
|---|---|---|---|
Collagens | COL3A1 | Methotrexate resistance, apoptosis | [27] |
Tumstatin | Cell proliferation, apoptosis | [124] | |
Endostatin | Metastases | [125] | |
Fibronectin | Fibronectin | Doxorubicin sensitivity | [36] |
Integrins | Cell proliferation, metastasis | [129] | |
Proteoglycans | Decorin | Cell invasion, metastasis | [130] |
CD44 | Doxorubicin sensitivity | [54] | |