Fig. 2

Overview of selected cJun signalling pathways. In general, a stimulus is passed through a MAPK cascade (sometimes via a small G protein) to alter the activity of transcription factors which act upon the cJun gene; this changes expression of target genes by the formation of an AP-1 dimer which binds to TRE DNA. Exemplary pathways have been shown which are indicative of the general signalling through which a stimulus leads to cJun mediated cellular changes. The pathways are therefore not necessarily complete as well as some of these activations occurring indirectly. Created with Biorender.com