Selective antagonism of cJun for cancer therapy

Brennan, Andrew; Leech, James T.; Kad, Neil M.; Mason, Jody M.

doi:10.1186/s13046-020-01686-9

Journal of Experimental & Clinical Cancer Research

Table 1 Examples of specific cancer types linked to dysregulated activity of AP-1 family members. In brackets we have indicated whether evidence points to up- or down-regulation of the AP-1 family member

From: Selective antagonism of cJun for cancer therapy

AP-1 family member	Type of cancer	Up/down-regulation	References
cJun	Breast cancer	Upregulation	[12, 13]
	Colorectal cancer	Upregulation	[14]
	Fibrosarcoma	Upregulation	[15]
	Glioma	Upregulation	[16]
	Hodgkin lymphoma	Upregulation	[17]
	Lung cancer	Upregulation	[18]
	Myeloid leukaemia	Upregulation	[19]
	Urothelial carcinoma of the bladder	Upregulation	[20]
JunB	Breast cancer	Upregulation	[21]
	Cervical cancer	Upregulation	[22]
	Colon cancer	Upregulation	[23]
	Fibrosarcoma	Upregulation	[15]
	Head and neck squamous cell carcinoma	Upregulation	[24]
	Hodgkin lymphoma	Upregulation	[17]
	Prostate cancer	Downregulation	[25]
JunD	Cervical cancer	Upregulation	[22]
JunD	Prostate cancer	Upregulation	[26, 27]
cFos	Breast cancer	Upregulation	[28]
	Cervical cancer	Upregulation	[22]
	Colon cancer	Upregulation	[23]
	Gastric cancer	Downregulation	[29]
	Head and neck squamous cell carcinoma	Upregulation	[30]
	Ovarian cancer	Downregulation	[31]
	Pancreatic cancer	Upregulation	[32]
	Skin cancer	Upregulation	[33]
	Tongue cancer	Upregulation	[34]
	Urothelial carcinoma of the bladder	Upregulation	[20]
FosB	Breast cancer	Downregulation	[35]
	Colon cancer	Downregulation	[23]
	Gastric cancer	Downregulation	[36]
	Non-small cell lung cancer	Downregulation	[37]
	Ovarian cancer	Upregulation	[38]
	Pancreatic cancer	Downregulation	[39]
Fra1	Breast cancer	Upregulation	[40]
	Cervical cancer	Downregulation	[22]
	Colon cancer	Upregulation	[41]
	Liver cancer	Upregulation	[42]
	Lung cancer	Upregulation	[43]
	Skin and hand and neck squamous cell carcinoma	Upregulation	[44]
Fra2	Breast cancer	Upregulation	[45]
	Non-small cell lung cancer	Upregulation	[46]
	Tongue cancer	Upregulation	[34]

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ISSN: 1756-9966

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