Fig. 5

STAT1 is a functional target of miR-382–3p and regulated by PSMB8-AS1. a Bioinformatic prediction of the potential binding site of miR-382–3p and STAT1. b Luciferase reporter assay analysis showing that the interaction with miR-382–3p and STAT1. c Spearman’s rank correlation showing the negative correlation between miR-382–3p and STAT1. d-e qPCR and western blot assay indicating that STAT1 was downregulated in the miR-382–3p overexpression PANC-1 and Mia paca2 cells. f-g CCK8 and clone formation eluted miR-382–3p overexpress could partly restrained the proliferation promoted by STAT1. h-i Cell scratch and transwell assay eluted miR-382–3p overexpress could partly restrained the migration and invasion promoted by STAT1