Fig. 5
From: Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib
CQ potentiates PON-induced cytotoxicity in the neuroblastoma mice model. a The treatment scheme is presented. Mice (n = 8 per group) orthotopically injected with IMR-32 cells were treated every day for 16 days, as graphically represented. b Treatments (T) started 12 days after tumor cell implantation. Survival: *p < 0.05, PON vs CTRL; **p < 0.01, COMBO vs CTRL; *p < 0.05, COMBO vs PON. c IMR-32–bearing mice (n = 5 per group) were treated as above and sacrificed 24 h after the last day of treatment. *p < 0.05, PON vs CTRL; **p < 0.01, COMBO vs CTRL