Fig. 2
From: CDK4/6 inhibitors: a novel strategy for tumor radiosensitization
Specific targets of CDK4/6 inhibitors. CDK4/6 inhibitors specifically bind to CDK4/6, thus inducing G1 phase arrest. Although these inhibitors perform the same function in cell cycle progression, their targets are slightly different. Palbociclib inhibits cyclin D1-CDK4, cyclin D2-CDK6, and cyclin D3-CDK4. Ribociclib targets cyclin D1-CDK4 and cyclin D3-CDK6. Abemaciclib targets cyclin D1-CDK4/6