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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop

Fig. 3

Downregulation of LPP-AS2 suppresses glioblastoma progression in vivo. a Schematic diagram of the entire experimental process. The divergent arrows suggest the different stages (first, inject tumor cells; second, tumor formation; third, measure tumor size; fourth, tissue harvesting and treatment). b, c Representative images of tumor formation of the lv-sh-control group and lv-sh-LPP-AS2 group. The dissected tumors from two groups were photographed. d Tumor volume was measured every 3 days. e Volumes of xenograft tumors in lv-sh-LPP-AS2 group and lv-sh-control group. f Weights of xenograft tumors in lv-sh-LPP-AS2 group and lv-sh-control group. g Relative expression of LPP-AS2 in Xenograft tissues were measured by RT-qPCR. h IHC staining revealed that transfection of lv-sh-LPP-AS2 contributed to decreased Ki-67, MMP9 and EGFR expression in the subcutaneous tumors. Data represent the mean ± s.e.m. of three independent experiments. *P < 0.05; **P < 0.01; (Student’s t test)

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