Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy

Table 1 Proteins that Promote the Stability of HIF

Cancer	Protein	Mechanism	Ref
liver, cervical	Bclaf1	Myb region of Bclaf1 participates in binding HIF-1α	[38]
lung	AK4	increase ROS levels	[33]
breast	HER2	/	[39]
liver	YAP	/	[40]
breast	FOXA1	/	[41]
breast	BRCA1-IRIS	prevents GSK-3β phosphorylation-driven degradation	[34]
breast	P4HA1	regulates the levels of 2-OG and succinic acid	[36]
myeloma	TRIM44	as a deubiquitinase of HIF-1α	[42]
colorectal	SOD3	decreases the activity of HIF-prolyl hydroxylase domain-containing protein	[43]
pancreatic	β-catenin	extends the half-life of HIF-2α	[37]
head and neck	GATA3	/	[44]

ISSN: 1756-9966