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Table 1 Proteins that Promote the Stability of HIF

From: Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy

Cancer Protein Mechanism Ref
liver, cervical Bclaf1 Myb region of Bclaf1 participates in binding HIF-1α [38]
lung AK4 increase ROS levels [33]
breast HER2 / [39]
liver YAP / [40]
breast FOXA1 / [41]
breast BRCA1-IRIS prevents GSK-3β phosphorylation-driven degradation [34]
breast P4HA1 regulates the levels of 2-OG and succinic acid [36]
myeloma TRIM44 as a deubiquitinase of HIF-1α [42]
colorectal SOD3 decreases the activity of HIF-prolyl hydroxylase domain-containing protein [43]
pancreatic β-catenin extends the half-life of HIF-2α [37]
head and neck GATA3 / [44]