Fig. 2From: Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the darkNATs in epigenetic modifications. aHOTAIR acts as a scaffold to tether the PRC2 and LSD1 complex and mediates H3K27 trimethylation and H3K4 demethylation. b NATs can interact, directly or indirectly, with DNA methyltransferases (DNMT3a) and guide DNA methylation, resulting in the repression of sense RNA transcriptionBack to article page