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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark

Fig. 3

NATs in transcriptional interference. In the initiation phase: a Promoter competition, the promoters of sense and antisense genes compete for RNAP complex; b Dislodgement, the RNAP complex of the sense gene promoter is dislodged by the arrival of the antisense gene RNAP complex; c Occlusion, the promoter of the sense gene is occluded by the antisense RNAP complex during antisense transcript elongation. In the elongation phase: d Collision, RNAP complexes collide in the overlapping region of the sense and antisense genes, blocking further transcriptions; e Roadblock, the antisense gene RNAP complex blocks that of the sense gene promoter. Ps, promoter of sense gene; Pa: promoter of antisense gene

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