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Table 1 Association of CRT and IRE1α expression with clinicopathological data in PC patients

From: Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress

Parameters No. of patients CRT P IRE1α P
Low High Negative Positive
Cases 81 31 50   43 38  
Age (years)
  ≤ 65 63 25 38 0.625 36 27 0.171
  > 65 18 6 12   7 11  
Gender
 Male 47 19 28 0.639 21 26 0.075
 Female 34 12 22   22 12  
Tumor location
 Head 57 21 36 0.683 30 27 0.899
 Body-tail 24 10 14   13 11  
Tumor size (cm)
  < 3 24 7 17 0.274 13 11 0.899
  ≥ 3 57 24 33   30 27  
Differentiation
 Well 22 7 15 0.466 12 10 0.872
 Moderate and poor 59 24 35   31 28  
T stage
 T1 + T2 72 30 42 0.157 37 35 0.609
 T3 + T4 9 1 8   6 3  
Lymph nodes metastasis
 N0 (negative) 65 30 35 0.003 30 35 0.012
 N1 (positive) 16 1 15   13 3  
UICC stage
 I + IIA 62 29 33 0.004 27 35 0.002
 IIB + III 19 2 17   16 3  
Perineural invasion
 Absent 70 28 42 0.636 37 33 0.917
 Present 11 3 8   6 5  
Vascular permeation
 Absent 49 15 34 0.079 28 21 0.365
 Present 32 16 16   15 17  
Pre-therapeutic CA19–9 level (U/ml)
  < 37 22 12 10 0.066 8 14 0.066
  ≥ 37 59 19 40   35 24  
Postoperative liver metastasis
 Negative 54 23 31 0.258 27 27 0.431
 Positive 27 8 19   16 11