Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress

Table 1 Association of CRT and IRE1α expression with clinicopathological data in PC patients

Parameters	No. of patients	CRT		P	IRE1α		P
Parameters	No. of patients	Low	High	P	Negative	Positive	P
Cases	81	31	50		43	38
Age (years)
≤ 65	63	25	38	0.625	36	27	0.171
> 65	18	6	12		7	11
Gender
Male	47	19	28	0.639	21	26	0.075
Female	34	12	22		22	12
Tumor location
Head	57	21	36	0.683	30	27	0.899
Body-tail	24	10	14		13	11
Tumor size (cm)
< 3	24	7	17	0.274	13	11	0.899
≥ 3	57	24	33		30	27
Differentiation
Well	22	7	15	0.466	12	10	0.872
Moderate and poor	59	24	35		31	28
T stage
T1 + T2	72	30	42	0.157	37	35	0.609
T3 + T4	9	1	8		6	3
Lymph nodes metastasis
N0 (negative)	65	30	35	0.003	30	35	0.012
N1 (positive)	16	1	15		13	3
UICC stage
I + IIA	62	29	33	0.004	27	35	0.002
IIB + III	19	2	17		16	3
Perineural invasion
Absent	70	28	42	0.636	37	33	0.917
Present	11	3	8		6	5
Vascular permeation
Absent	49	15	34	0.079	28	21	0.365
Present	32	16	16		15	17
Pre-therapeutic CA19–9 level (U/ml)
< 37	22	12	10	0.066	8	14	0.066
≥ 37	59	19	40		35	24
Postoperative liver metastasis
Negative	54	23	31	0.258	27	27	0.431
Positive	27	8	19		16	11

ISSN: 1756-9966