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Table 1 Association of CRT and IRE1α expression with clinicopathological data in PC patients

From: Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress

Parameters

No. of patients

CRT

P

IRE1α

P

Low

High

Negative

Positive

Cases

81

31

50

 

43

38

 

Age (years)

  ≤ 65

63

25

38

0.625

36

27

0.171

  > 65

18

6

12

 

7

11

 

Gender

 Male

47

19

28

0.639

21

26

0.075

 Female

34

12

22

 

22

12

 

Tumor location

 Head

57

21

36

0.683

30

27

0.899

 Body-tail

24

10

14

 

13

11

 

Tumor size (cm)

  < 3

24

7

17

0.274

13

11

0.899

  ≥ 3

57

24

33

 

30

27

 

Differentiation

 Well

22

7

15

0.466

12

10

0.872

 Moderate and poor

59

24

35

 

31

28

 

T stage

 T1 + T2

72

30

42

0.157

37

35

0.609

 T3 + T4

9

1

8

 

6

3

 

Lymph nodes metastasis

 N0 (negative)

65

30

35

0.003

30

35

0.012

 N1 (positive)

16

1

15

 

13

3

 

UICC stage

 I + IIA

62

29

33

0.004

27

35

0.002

 IIB + III

19

2

17

 

16

3

 

Perineural invasion

 Absent

70

28

42

0.636

37

33

0.917

 Present

11

3

8

 

6

5

 

Vascular permeation

 Absent

49

15

34

0.079

28

21

0.365

 Present

32

16

16

 

15

17

 

Pre-therapeutic CA19–9 level (U/ml)

  < 37

22

12

10

0.066

8

14

0.066

  ≥ 37

59

19

40

 

35

24

 

Postoperative liver metastasis

 Negative

54

23

31

0.258

27

27

0.431

 Positive

27

8

19

 

16

11