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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: The role of TRPV1 ion channels in the suppression of gastric cancer development

Fig. 5

Changes in tumor-related signaling molecules after genetic manipulation of TRPV1 in GC cells. a Screening of phosphorylation of 40 key cancer-related signaling molecules analyzed by signaling pathway phosphorylation microarray after TRPV1 overexpression in BGC823 cells (*P < 0.05, n = 3). b ERK1/2 phosphorylation in TRPV1-overexpressed BGC823 cells and TRPV1-knockeddown MKN45 cells. Representative images are shown on the left and summary data on the right (*P < 0.05 vs. NC, n = 3). c, d Phosphorylation of β-catenin and AKT in TRPV1-overexpressed BGC823 cells and TRPV1-knockeddown MKN45 cells (NS: no significant difference, vs. NC, n = 3). e AMPK mRNA levels in TRPV1-overexpressed BGC823 or TRPV1-knockeddown MKN45 cells (NS: no significant difference, vs. NC, n = 3). f AMPK phosphorylation after TRPV1 overexpression in BGC823 cells and AMPK knockdown in TRPV1-overexpressed BGC823 cells (*P < 0.05, n = 3). g AMPK phosphorylation after TRPV1 knockdown in MKN45 cells and AMPK overexpression in TRPV1-knockeddown MKN45 cells (*P < 0.05, n = 3)

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