Fig. 4
From: TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients
TMPRSS2 gene methylation status in normal and tumoral samples of HNSCC and lung cancer patients. a DNA methylation profile of TMPRSS2 gene in normal (blue line) and tumoral (red line) samples of HNSCC TCGA patients. b Box-plot analysis representing TMPRSS2 gene expression levels in non-tumorous (N) and tumor (T) tissues from the lung adenocarcinoma (LUAD) TCGA dataset. c DNA methylation profile of TMPRSS2 gene in normal (blue line) and tumoral (red line) samples of LUAD TCGA patients. d Box-plot analysis representing TMPRSS2 gene expression levels in non-tumorous (N) and tumor (T) tissues from the lung squamous cell carcinoma (LUSC) TCGA dataset. e DNA methylation profile of TMPRSS2 gene in normal (blue line) and tumoral (red line) samples of LUAD TCGA patients. DNA methylation profile has been performed by using Wanderer software. Beta values (β) are the estimate of methylation level using the ratio of intensities between methylated and unmethylated alleles. β values are between 0 and 1, with 0 being unmethylated and 1 fully methylated. The tool provides the detailed individual beta values of all the HumanMethylation450 probes inside or in the vicinity of the gene. Probes for the CpG island are indicated in green. Dotted red line indicates the threshold β value of 0.5