Fig. 4

Therapeutic efficiencies of anti-MET, anti-RON, and MET/RON dual targeting ADCs in CRAC xenograft models. Results shown here are from published articles. CRAC xenograft tumors used are initiated by SW-48 (for ABBV-399), HCT-116 (for Zt/g4-MMAE), and HT29 (for PCM5B14-DCM) cell lines, respectively. The CR3150 PDX model is used for TR1801-ADC. The gastric tumor model initiated by MKN-45 is used for SHR-A1403. Individual ADCs are used at different doses in a different schedule or in combination with chemotherapeutics. Tumor volumes from control and ADC treated animals were measured to determine the ADC efficacy. In some cases, tumoristatic concentrations (TSCs) are calculated. It needs to be mentioned that studies shown here vary significantly with different CRAC cell lines, variable doses and treatment schedules, and with or without chemotherapeutics. Thus, results are not intent for comparison of therapeutic efficacies among individual ADCs. Instead, it is only to confirm the anticancer activity under their own doses and treatment schedules. FOLFIRI, a standard CRAC treatment regimen composed of 5-fluorouracil, irinotecan, and leucovorin; SHR152852, an auristatin analog as the payload for SHR-A1403; and SKM-SG3249, an ADC composed of the monoclonal antibody secukinumab to interleukin-17A conjugated with PBD DNA cross-linker SG3249