Fig. 4

Genomically-distinct HNSCC PDX models develop resistance to alpelisib following prolonged treatment. a Growth curves for PDX models treated over time with alpelisib. 5 mice per arm received either alpelisib (50 mg/kg) or a vehicle agent (corn oil). * represents p < 0.05, ** represents p < 0.01, unpaired Student’s t-test. Boxed out region highlights early treatment days where alpelisib-treated tumors showed static growth relative to the vehicle treatment. b Representative IHC sections showing TYRO3 staining in PDX-C and PDX-E models. Quantification was completed using Fiji software and is shown below. * represents p < 0.05, unpaired Student’s t-test. Scale bars represent 100 μM