Fig. 3
From: RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer
Knockdown of IGF2BP3 promoted cell cycle arrest and repressed proliferation of colon cancer cells. a. The expression of IGF2BP3 in various colon cancer cell lines performed by Western Blotting analysis. b. Knockdown of IGF2BP3 in HCT-116 and RKO confirmed by Western Blotting analysis. c. Knockdown of IGF2BP3 promoted cell cycle arrest in both HCT-116 and RKO. Cell cycle was measured by flowcytometry. (***Compare between percentage of G0/G1 phase, P<0.001; ###Compare between percentage of S phase, P<0.001). D. Knockdown of IGF2BP3 inhibited the clone formation ability of HCT-116 and RKO cells. (***P<0.001)