Fig. 7

Deregulation of lncRNA RP11-757G1.5 suppresses CRC cell proliferation and invasion in CRC orthotopic xenografts. a-e Representative IVIS images of tumor size (a), macroscopic appearance (b), tumor growth curves (c), tumor weight (d), and metastasis (e) in pcDNA3.1-757G1.5 group vs control group. Scale bar, 100 μm. f-j Representative IVIS images of tumor size (f), macroscopic appearance (g), tumor growth curves (h), tumor weight (i), and metastasis (j) in sh-757G1.5#1 group vs control group. k-l Representative macroscopic appearance and IVIS image of metastatic foci (white arrows) in the liver (k) and spleen (l). Each sample was run in triplicate and in multiple experiments. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01 by Student’s t-test. Data were shown as mean ± SD for three independent experiments