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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: HDAC3 deteriorates colorectal cancer progression via microRNA-296-3p/TGIF1/TGFβ axis

Fig. 5

Restored miR-296-3p or depleted TGIF1/HDAC3 slows down tumor growth in nude mice with CRC. a. Representative images of xenografted tumors in nude mice in each group; b. Volumes of xenografted tumors in nude mice in each group; c. Weights of xenografted tumors in nude mice in each group; d. TUNEL staining (× 200) of xenografted tumor tissues; e. Apoptotic index of xenografted tumor tissues in nude mice in each group; f. RT-qPCR detection of TGF-β1, Smad2 and Smad3 mRNA expression in xenografted tumor tissues in nude mice in each group; g. HE staining of xenograft tumor tissues in each group (× 200). n = 5. One-way ANOVA was utilized for comparisons among multiple groups, followed by Tukey’s multiple comparisons test. * represented P < 0.05, ** represented P < 0.01, *** represented P < 0.001

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