Table 1 Primer sequences

miR-296-3p

F: 5′-GAGGGTTGGGTGGAGGCTCTCC −3′

The reverse primers of miR-296-3p used universal primers

U6

F: 5′-ATGACACGCAAATTCGTGAAGC-3′

The reverse primers of U6 used universal primers

HDAC3

F: 5′-GGAGCTGGACACCCTATGAA-3

R: 5′-TATTGGTGGGGCTGACTCTC-3′

TGIF1

F: 5′-AGATCTGAATTGTGCCAGTGTTTCTCTTTG-3′

R: 5′-CCATGGCGGCGCTTCAGAGTGAG-3′

TGF-β

F: 5′-GCAAGTGGACATCAACGGGTTC-3′

R: 5′-CGCACGCAGCAGTTCTTCTC-3′

Smad2

F: 5′-CGTCCATCTTGCCATTCACG-3′

R: 5′-CTCAAGCTCATCTAATCGTCCTG-3’

Smad3

F: 5′-GGACGCAGGTTCTCCAAAC-3’

R: 5′-CGGCTCGCAGTAGGTAA-3’

PCNA

F: 5′-CGGATACCTTGGCGCTAGTA-3’

R: 5′-TCACTCCGTCTTTTGCACAG-3’

Ki-67

F: 5′-GAGAGCTCCCAGCCTAAGGT-3’

R: 5′-TGCACACCTCTTGACACTCC-3’

MMP2

F: 5′-CCGTCGCCCATCATCAAGTT-3’

R: 5′-CTGTCTGGGGCAGTCCAAAG-3’

MMP9

F: 5′-CATTTCGACGATGACGAGTTGT-3’

R: 5′-CGGGTGTAGAGTCTCTCGC-3’

GAPDH

F: 5′-GACAACAGCCTCAAGATCATCAG-3’

R: 5′-GTGGCAGTGATGGCATGGA-3’