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Table 4 Possible mechanisms of HPD involving the interaction between the ICI Fc domain and macrophage Fc receptors

From: Mechanisms of hyperprogressive disease after immune checkpoint inhibitor therapy: what we (don’t) know

  1. The engagement of an unidentified Fc receptor expressed by TAMs by the anti-PD-1 antibody Fc domain may directly trigger a functional reprogramming of these immune cells or may induce the clustering of PD-1 on macrophages, leading, in both cases, to the acquisition of an enhanced pro-tumor phenotype