Fig. 4

Linc00337 regulates cell cycle associated pathways. a, Venn diagram depicting differentially expressed genes (DEGs) regulated by Linc00337 in stably-transfected AsPC1 and PANC1 cells (DEGs with |fold change| > 2, FDR < 0.05). b and c, GO enrichment (b) and string (c) analysis of common DEGs showing the top pathways associated with cell cycle and cell division. d, GSEA of RNA-seq data from PANC1 (top) and AsPC1 (bottom) stably transfected cells with the indicated gene set. e, Western blot analysis of the indicated cell cycle-associated proteins in PANC1 and AsPC1 stable cell lines, the bands were quantified by image J software. In (a-c), RNA-seq was repeated twice; in (d), experiment was repeated three times