Fig. 7

Linc00337 via regulating E2F1 to exert its oncogenic roles in PDAC cells. a-c, TCGA data revealing that E2F1 is highly expressed in PDAC tissues (a), correlates positively with Linc00337 (b), and predicts poor prognosis (c). d-f, E2F1 partly rescues cell proliferation repressed by Linc00337 knockdown in PANC1 cells as indicated by CCK8 cell viability assays (d), the inhibitory ratio (e), and colony formation assays (f). g-i: Xenograft subcutaneous tumor formation assays with indicated stably-transfected PANC1 cells showing tumor size (g), growth curve (h), weight (i). In (d-f), data represent the mean ± SD of three or four independent experiments