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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression

Fig. 1

Generation of DM-type micronuclei. a. DMs are located on the nuclear periphery during the G1 phase and move to the interior during their replication in the early S phase. Acentric DMs segregate by adhering to the chromosome arm during the M phase, which is called ‘hitchhiking.’ b. In cells exposed to a low dose of HU during the early S phase, DMs tend to aggregate and detach from the chromosome during the subsequent M phase. Then, the aggregated DMs generate micronuclei during the subsequent interphase

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