Fig. 1From: Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progressionGeneration of DM-type micronuclei. a. DMs are located on the nuclear periphery during the G1 phase and move to the interior during their replication in the early S phase. Acentric DMs segregate by adhering to the chromosome arm during the M phase, which is called ‘hitchhiking.’ b. In cells exposed to a low dose of HU during the early S phase, DMs tend to aggregate and detach from the chromosome during the subsequent M phase. Then, the aggregated DMs generate micronuclei during the subsequent interphaseBack to article page