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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression

Fig. 4

ecDNA-mediated oncogene amplification promotes tumor progression. In NB, MYCN encoded by ecDNA is closely associated with tumor progression. In glioblastoma, the amplification of oncogenes, such as MYC, EGFR, PDGFRα, ERBB2, CDK4, and MDM2, on ecDNA promotes tumorigenesis. In breast cancer, HER2 encoded on ecDNA contributes to tumorigenesis. In ovarian cancer, ecDNA containing MYCN and EIF5AR stimulates tumorigenesis. In colon cancer, DHFR amplification via ecDNA is also involved in tumorigenesis

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