Fig. 2

CUDC-907 results in dose-dependent downregulation of MYC paralogs and DDR pathway genes. a Western blot analysis of the basal expression of MYC paralogs in a panel of SCLC cell lines. b, c Western blot analysis of MYC paralogs in cells with amplification of MYC paralogs (b) and DDR pathway genes (c) in a panel of SCLC cell lines after treated with increased concentrations of CUDC-907 for 24 h