Fig. 1

The genetic landscape of KRAS wild-type pancreatic ductal adenocarcinoma (PDAC) is shown. The vast majority of cases harbored KRAS mutations, but about 8–10% of cases show other molecular alterations, including microsatellite instability (MSI) – high tumor mutational burden (hTMB), kinase fusion genes, and activation of the MAPK pathway without KRAS involvement