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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation

Fig. 4

Role of HIF-α on fatty acids metabolism during cancer progression via epigenetic regulation. Two FAO enzymes, the acyl-CoA dehydrogenases MCAD and LCAD, are inhibited by the activated HIF-1α under hipoxia. LCAD and MCAD loss disturbs the process of FAO which leads to ROS alteration via TCA (tricarboxylic acid) cycle and separate LCAD loss inhibits PTEN pathway, which finally mediate resistance to tumor progression. HIF-1α loss-of-function may rescues the resistance and contributes to cancer progression. CS: citrate synthase; ACL: acetone-cyanohydrin lyase; ACC: acetyl-CoA carboxylase alpha

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