Fig. 4

Gene expression profiling of TNBC cell lines as effect of multiple dose exposure on doxorubicin therapy. Genes Heatmaps emphasizing the altered genes signature at passage P12 and P24 in a Hs578T cell line and b MDA-MB-231 cell line. Venn diagram of the statistically determined (FC ± 2 and p-value ≤0.05) upregulated and downregulated genes expressions by overlapping both TNBC cell lines. c, d Highlighted the common overexpressed gene expression signature at P12, respectively P24; e, f common downregulated gene expression signature at P12, respectively P24; g, h common upregulated lncRNAs expression signature at P12, respectively P24; i, j common downregulated lncRNAs signature at P12, respectively P24