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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Targeting HMGB3/hTERT axis for radioresistance in cervical cancer

Fig. 6

High expression of HMGB3/hTERT predicted poor prognosis in patients with cervical cancer. a The expression of HMGB3 and hTERT were detected in the cervical cancer tissue and corresponding adjacent of 8 patients by western blot. b HMGB3/hTERT expression analysis form GEO database (GSE7803). A tissue microarray containing 119 cervical cancer patients was used for further study. The tumor tissue samples (tumor and adjacent tissue) were took from patients who had not undergone anti-tumor therapy since diagnosis, with all of the information from patients authenticated. c The level of HMGB3 and hTERT in the normal cervical epithelium, high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cell carcinoma (CSCC) (cervical cancer tissue microarrays) were detected by immunohistochemistry. d Cox-regression analyses in a tissue microarray containing 119 cervical cancer patients. e Survival of the patients with different HMGB3 expression was analyzed by Kaplan–Meier analysis. f Overall survival of 119 cervical cancer patients with different HMGB3 and hTERT expression. gThe schematic diagram of the mechanism ofHMGB3/ hTERT axis in cervical cancer radioresistance

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