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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Ascorbic acid (vitamin C) synergistically enhances the therapeutic effect of targeted therapy in chronic lymphocytic leukemia

Fig. 4

AA-induced apoptosis is caspase-dependent. a: Western blot of PARP cleavage, cleaved caspase-3, cleaved caspase-8, and β-actin in OSU-CLL cells treated with 250 μM AA for 6 h in the presence or absence of sodium pyruvate (SP, 1 mM). b, c, and d: Quantification of cleaved PARP (n = 5) (B), cleaved caspase-3 (n = 5) (c) and cleaved caspase-8 (n = 3) (d), normalized against β-actin. Data are presented as the fold-change vs. the control (mean ± SEM) (*: p < 0.05, **: p < 0.01 vs. Ctrl)

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