Fig. 7

Ascorbic acid synergistically potentiates the effects of mitochondrial metabolism targeting therapies on CLL B-cells. a: Effects of metabolic enzyme inhibitors oligomycin A (5 μM), CPI-613 (100 μM) and metformin (1 mM) on the viability of CLL B-cells after treatment alone or in combination with 250 μM AA for 24 h (*: p < 0.05, **: p < 0.01, ***: p < 0.001; n = 5). Cell viability was determined by an annexinV/7AAD staining. Data are presented as the mean ± SEM. b: Table show the coefficient of drug interaction (CDI) for drug combination with AA showed in (a). CDI values < 0.7 were considered as synergistic