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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis

Fig. 7

Combination of evodiamine and PD-1 mAb treatment enhance tumor growth control and survival of the Lewis lung carcinoma model. a The survival rate of LLC and the combination of evodiamine and PD-1 mAb improves the survival of the mice. b The body weight of mice does not change. Tumor volume is checked at the beginning of the treatment period. The combination evodiamine and PD-1 mAb treatment enhanced inhibits tumor growth in the Lewis lung carcinoma model (c-e), The efficacy of anti-tumor growth is estimated by measuring tumor volume (c), tumor size (d) and tumor weight (e). h Lymphocytes cells are analyzed using flow cytometry with FIN-γ, TNFα and Granzyme B, CD4 and CD8 antibodies. The results were presented in three independent experiments with the mean ± S.D. (n = 3, *P < 0.05; **P < 0.01; ***P < 0.001)

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